Aging cells accumulate damaged and misfolded proteins through a functional decline in their protein homeostasis (proteostasis) machinery, leading to reduced . We propose that the collapse of proteostasis represents an early molecular event of aging that amplifies protein damage in age-associated. Proteostasis, a portmanteau of the words protein and homeostasis, is the concept that there are Cellular proteostasis is key to ensuring successful development, healthy aging, resistance to 2 Signaling events in proteostasis . capacity, proteostatic collapse occurs and chaperone production is severely impaired.

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Shock Protein Misfolding Disorders. Citations Publications citing this paper. Showing of extracted citations. Physiological and pathological significance of the molecular cross-talk between autophagy and apoptosis.

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Short-term changes in diet composition do not affect in vivo hepatic protein synthesis in rats. Pagliassotti American journal of physiology.

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Showing of references. A phosphatidylinositolOH kinase family member regulating longevity and diapause xollapse Caenorhabditis elegans Jason Z. MorrisHeidi A. TissenbaumGary Ruvkun Nature Collapse of proteostasis represents an early molecular event in Caenorhabditis elegans aging. Anat Ben-ZviElizabeth A. MillerRichard I. Morimoto Proceedings of the National Academy of Sciences…. Induction of the heat shock pathway during hypoxia requires regulation of heat shock factor by hypoxia-inducible factor BairdDouglas W.

Regulation of aging and age-related disease by DAF and heat-shock factor. Ao-Lin HsuColeen T. MurphyCynthia Kenyon Science Morimoto PLoS genetics Kenyon PLoS genetics A role for autophagy in the extension of life – span by dietary restriction in C.


Promoting basal levels of autophagy in the nervous system enhances longevity and oxidant resistance in adult Drosophila.

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