Sign of Leser-Trélat. Authoritative facts about the skin from DermNet New Zealand. Leser-Trélat sign is a rare skin condition characterized by the sudden appearance of seborrheic keratoses that rapidly increase in number and size within weeks. Images in Clinical Medicine from The New England Journal of Medicine — The Sign of Leser–Trélat.

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Examination of the abdomen disclosed moderate hepatosplenomegaly. Possible role of retinoid therapy. Indian J Dermatol Venereol Leprol.

Leser–Trélat sign – Wikipedia

Sign in to save your search Sign in to your personal account. Epub Jan Seborrheic keratoses and cancer.

In addition, symptomatic lesions may be destroyed with various physical methods including cryotherapy, curettage, shave removal, and electrodesiccation. Please review our privacy policy.

Malignant Neoplasms and the Leser-Trélat Sign | JAMA Dermatology | JAMA Network

Because seborrhoeic keratoses and cancer are both statistically more common in elderly people it is difficult to ascertain whether the keratoses is due to the cancer ie: They appear as brown warty nodules with a stuck-on appearance. Lsser, given the abrupt onset of the seborrheic keratoses and their distinctive appearance misdiagnosis as another cutaneous entity would be unlikely.


This can be an ominous sign of internal malignancy as part of a trelag syndrome. Images in clinical medicine. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic.

A possible role of a cutaneous marker for internal malignancy. How to cite this URL: Seborrheic keratoses of florid eruption.

DermNet NZ does not provide an online consultation service. Online since 15 th March ‘ However, the sudden eruption of seborrhoeic keratoses in young patients points to a paraneoplastic process and should prompt an investigation for a hidden cancer. Our website uses cookies to enhance your experience. The Oxford illustrated companion to medicine. Leser Trelat Sign – StatPearls. CA Cancer J Clin. Physical examination will typically reveal numerous seborrheic keratoses usually in a symmetric pattern on the back that may resemble a “Christmas tree,” “splash,” lwser “raindrop” pattern.

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Sign of Leser-Trélat

The sign of Leser-Trelat. Published by Wolters Kluwer – Medknow. Laboratory evaluation including a complete blood count CBC and complete metabolic panel CMP should be obtained along with gender-specific cancer screenings such as mammography, Pap smears, and prostate serum antigen PSA testing. As previously mentioned, seborrheic keratoses are a nearly ubiquitous, benign skin lesion in patients greater than lesef years of age.


Lesr paraneoplastic syndromes in solid tumors. It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses. The presence of horn cysts on the surface of the lesions is also classic. Additional named growth factors include human-growth-hormone, transforming growth factor-alpha, and insulin-like growth factor.

Any of these distinct variations may also become irritated or inflamed, displaying either squamous eddy signn spindled cells or lymphocyte infiltration, respectively. Author Information Authors Courtney N.

Leser–Trélat sign

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Various subtypes of seborrheic keratoses exist including acanthotic most common varianthyperkeratotic, reticulated, clonal and melanoacanthoma.